What are aromatase inhibitors for breast cancer, and how do they work?

What are aromatase inhibitors for breast cancer, and how do they work?

In this case your specialist will tell you how long to take the medicine for. This varies for each person and includes factors like your age when the breast cancer was found, how it was found and whether you’ve had chemotherapy or not. They can also calculate how well anastrozole is likely to work for you.

Ovarian suppression prevents the ovaries from making estrogen, so a woman becomes postmenopausal. Ovarian suppression is usually done with drug therapy, so menopause may be temporary. Aromatase inhibitors are used to treat breast cancer in women.

Your health care provider may also switch you to another aromatase inhibitor (you may have less pain with a different drug) or recommend tamoxifen [19]. Almost half of women taking aromatase inhibitors have joint pain and about 15 percent have muscle pain [ ]. Women usually begin the drug after undergoing surgery to remove a breast tumor. They typically remain on the drugs for five to 10 years, depending on how likely the cancer is to return.

  • However, these drugs have not yet received FDA approval for this use.
  • A breast cancer diagnosis after menopause can be overwhelming.
  • However, some people find that they start to having periods again after taking anastrozole.
  • No dose adjustment is necessary for patients with renal or liver impairment or elderly patients.
  • You are most likely to have anastrozole or letrozole for 5 years.

Aromatase inhibitors should not be used in people with a known hypersensitivity to any of the active or inactive ingredients in the drug. With that being said, a drug allergy is not common with aromatase inhibitors, affecting less than one out of 10,000 users. After five years of use, an estimated one of out of every 10 women on aromatase inhibitors will experience a fracture due to drug-induced osteoporosis.

Stopping the ovaries producing oestrogen using surgery, drugs or radiotherapy. Research suggests the common table mushroom has anti-aromatase[22] properties and therefore possible anti-estrogen activity. Treatment withtamoxifen for two to five years before https://joseysnatural.com/new-study-finds-optimal-dosage-of-toremifene-for/ may slow down the rate of bone loss.

International Patients

Women with pre-existing heart disease who take an AI may be at higher risk of having a heart problem.

If you can’t have surgery

Aromatase inhibitors don’t normally work in premenopausal women because their ovaries are still making estrogen. Learn about the importance of completing treatment with an aromatase inhibitor. To learn about a specific aromatase inhibitor, visit the National Institutes of Health’s Medline Plus website. Most people can eat and drink normally when taking anastrozole.

Before menopause, the ovaries produce most of the body’s estrogen. Exemestane, another selective agent, comes in 25 mg tablets, and for postmenopausal breast cancer, dosing is 25 mg daily for 2 to 3 years. However, some people may get on better with one drug than another. Armidex, Aromasin, and Femara can cause fetal harm and should not be used if there is any chance of pregnancy. As a safeguard, pregnancy testing is recommended seven days prior to the start of treatment if a woman’s menopausal status is unknown.

By taking this medicine for 5 years, you have a better chance of being alive 15 years after your breast cancer was first diagnosed. Anastrozole helps stop your breast cancer coming back after having treatment for cancer. There are very few medicines that affect the way anastrozole works in the body. For a full list, see the leaflet inside your medicines packet. Like all medicines, anastrozole can cause side effects, although not everyone gets them.